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Habib Nouri Ferjani Ben Hmida Moez Ouertatani Mouna Bouaziz Leila Abid Habib Jaafoura Kheireddine Zehi Mondher Mestiri 《Knee surgery, sports traumatology, arthroscopy》2010,18(10):1391-1394
Three different tumour-like lesions within the infrapatellar fat pad, an osteochondroma, a localised pigmented villonodular synovitis and a synovial cyst are reported. The osteochondroma and the pigmented villonodular synovitis were treated by marginal excision, and the synovial cyst was resected using arthroscopy. 相似文献
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Suzanne Lesage PhD Ariane Lunati MSc Marion Houot MSc Sawssan Ben Romdhan PhD Fabienne Clot PhD Christelle Tesson PhD Graziella Mangone MD Benjamin Le Toullec MSc Thomas Courtin MSc Kathy Larcher MSc Mustapha Benmahdjoub MD Mohamed Arezki MD Ahmed Bouhouche MD Mathieu Anheim MD Emmanuel Roze MD François Viallet MD François Tison MD Emmanuel Broussolle MD Murat Emre MD Hasmet Hanagasi MD Basar Bilgic MD Meriem Tazir MD Mouna Ben Djebara MD Riadh Gouider MD Christine Tranchant MD Marie Vidailhet MD Eric Le Guern MD Olga Corti PhD Chokri Mhiri MD Ebba Lohmann MD Andrew Singleton PhD Jean-Christophe Corvol MD Alexis Brice MD for the French Parkinson Disease Genetics Study Group 《Annals of neurology》2020,88(4):843-850
Studies of the phenotype and population distribution of rare genetic forms of parkinsonism are required, now that gene-targeting approaches for Parkinson disease have reached the clinical trial stage. We evaluated the frequencies of PRKN, PINK1, and DJ-1 mutations in a cohort of 1,587 cases. Mutations were found in 14.1% of patients; 27.6% were familial and 8% were isolated. PRKN was the gene most frequently mutated in Caucasians, whereas PINK1 mutations predominated in Arab-Berber individuals. Patients with PRKN mutations had an earlier age at onset, and less asymmetry, levodopa-induced motor complications, dysautonomia, and dementia than those without mutations. ANN NEUROL 2020;88:843–850 相似文献
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Hana Sahli Asma Bachali Lamine Hamzaoui Mouna Medhioub Aida Bachrouch Khaled Bouzaidi Rawdha Tekaya Msaddak Azzouz 《The Egyptian Rheumatologist》2018,40(3):187-190
Aim of the work
To determine the frequency, clinical and radiological features of axial spondyloarthritis in patients with inflammatory bowel diseases (IBD) and to characterize differences between patients with and without axial spondyloarthritis.Patients and Methods
Patients included in this cross-sectional study were recruited from the Gastroenterology Department, University of Tunisia over six months. Sixty-four patients with IBD were questioned and examined for axial spondyloarthritis symptoms. Standard pelvic X-rays were performed for all and CT scans and MRI were done for some patients.Results
There were 42 men (65.6%) and 22 women (34.4%) with a mean age of 47?±?22 years. 32 patients (50%) had Crohn’s disease, 31 had ulcerative colitis and 1 patient has undifferentiated colitis. The disease was confined to the colon among a half of patients with ulcerative colitis. Regarding Crohn’s disease, all lesions were confined to the ileum and the colon. The mean IBD duration was 6.18±7.2 years. The occurrence of axial spondyloarthritis was 26.5% (17 patients who were symptomatic in 16 cases). The bowel disease preceded rheumatic manifestations in all cases. Nine patients (14.1%) had isolated sacroiliitis. The patients with and without axial spondyloarthritis had similar sociodemographic, anthropometric characteristics, comorbidities and bowel disease particularities except a higher percentage of corticosteroids use (p?=?.013).Conclusions
Due to the high frequency, an early diagnosis of spondyloarthritis in patients with inflammatory bowel disease by thorough clinical exam and standard pelvic X-rays should be recommended. 相似文献79.
Frédéric Tran Mau‐Them Aurélia Boualam Mouna Barat‐Houari Claire Jeandel Jérôme Cottalorda Valérie Cormier‐Daire Aurélie Fabre Bruno Dumont Geneviève Lefort Geneviève Baujat Martine Le Merrer Christian Jorgensen Isabelle Touitou David Geneviève 《American journal of medical genetics. Part A》2014,164(3):769-773
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Leila Ksiaa Cheikhrouhou Yousr Lakhoua-Gorgi Imen Sfar Salwa Jendoubi-Ayed Houda Aouadi Mouna Makhlouf Khaled Ayed Taieb Ben Abdallah 《World journal of gastroenterology : WJG》2015,21(35):10150-10158
AIM: To analyze the polymorphisms of CTLA-4 gene involved in the response against hepatitis C virus(HCV) infection.METHODS: We recruited 500 hemodialysed patients from several hemodialysis centers, all HCV-antibody positive, spread over different regions of Tunisia, as part of a national survey in 2008 conducted in the laboratory of immunology at the Charles Nicolle hospital Tunisia, classified into two groups G1(PCR+) and G2(PCR-) according to the presence or absence of viral RNA. Of these patients, 307 were followed prospectively on a viral molecular level over a period from 2002 to 2008, divided into two groups based on the persistence and viral clearance. PCR-RFLP was performed for the analysis of SNPs(+49) A/G and(+6230) G/A CTLA-4 for these 500 patients and 358 healthy controls.RESULTS: Analysis of clinical and virological charac-teristics of our cohort suggests a nosocomial infection in our hemodialysed patients with transfusion history as a primary risk factor and a predominance of genotype 1b. The haplotype analysis revealed an increase of frequencies of GG(+49)/(CT60) CTLA-4 in the entire patients group compared to controls(P = 0.0036 and OR = 1.42; 95%CI: 1.12-1.79, respectively). This haplotype is therefore associated with susceptibility to HCV infection. CONCLUSION: Our study suggests a possible role of CTLA-4 polymorphisms in the outcome of HCV infection in the Tunisian hemodialysed population. 相似文献